Although Regina Trench Cemetery is in the commune of Grandcourt, it is not possible to gain access to the cemetery from Grandcourt. Visitors should approach the cemetery from the direction of Courcelette, which is a village about 8 kilometres north-east of Albert (next to the main road D929 Albert-Bapaume). The cemetery lies about 1.5 kilometres north-west of the village of Courcelette (signposted in the centre of Courcelette) and will be found 1.5 kilometres down a single track lane (not suitable for cars).
On 1 July 1916, the first day of the Battle of the Somme, Grandcourt village was reached by part of the 36th (Ulster) Division, but it was not until the German withdrawal to the Hindenburg Line, early in February 1917, that it was occupied by patrols of the Howe Battalion, Royal Naval Division. To the south-east of it is Courcelette, taken by the 2nd Canadian Division on 15 September 1916. Regina Trench was a German earthwork, captured for a time by the 5th Canadian Brigade on 1 October 1916, attacked again by the 1st and 3rd Canadian Divisions on 8 October, taken in part by the 18th and 4th Canadian Divisions on 21 October, and finally cleared by the 4th Canadian Division on 11 November 1916. The original part of the cemetery (now Plot II, Rows A to D) was made in the winter of 1916-1917. The cemetery was completed after the Armistice when graves were brought in from the battlefields of Courcelette, Grandcourt and Miraumont; most date from October 1916 to February 1917. Two considerable groups of scattered graves, classed as cemeteries, were concentrated in to Regina Trench Cemetery:- COURCELETTE ROAD CEMETERY, MIRAUMONT, was on the West side of West Miraumont Road, between Courcelette and Miraumont, and in it were buried soldiers from Canada and from the United Kingdom, who fell in September-November 1916. MIRAUMONT BRITISH CEMETERY, on the East side of the same road, contained the graves of soldiers from Canada and from the United Kingdom, who fell in September-December 1916. Regina Trench Cemetery now contains 2,279 burials and commemorations of the First World War. 1,077 of the burials are unidentified, but there are special memorials to 14 casualties believed to be buried among them. One American airman is also buried in the cemetery. The cemetery was designed by Sir Herbert Baker.